As usual Python stuff for .NET is more advanced and evolving quicker than Ruby stuff.
Sad fact to me as (syntax-wise), I like Ruby much more!
Important: Read Installation Details Below
I haven’t tried yet but what they claim for IDE features specifically is really impressive (if works as in screenshots).
They also support multiple Python runtimes/environments (CPython, different versions of IronPython, PyPy).
Update
Before download, make sure to read the installation details carefully:
Installation Details (See the wiki page):
PTVS is an add-in for Visual Studio 2010. To get Visual Studio you have several options:
Get it through BizSpark (a program for startups): http://www.bizspark.com/Pages/home.aspx
Get it through DreamSpark (for schools/students): https://www.dreamspark.com/Products/Product.aspx?ProductId=25
Get it through your school: You might already have a license for VS – please contact your sys admin or professor.
Get it from the main site (try or buy): http://www.microsoft.com/visualstudio/en-us/